Can you confirm that the game is patched to the latest patch, i think if it was me i would do a clean install, patch to the latest patch, run the GWX 3 installer and see if the game will run, if you go this route, don't forget to delete the old SH3 folder (C:-Program Files-UBISOFT), BEFORE the fresh install.
The latest patch is the 1.4b, but you will need to install the other patches first.
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