Yikes, though its still early days for the A380, its probably still safer than the ageing 747 with its dodgy locking mechanism on the cargo doors, several 747s have had explosive decompressions that have claimed lives - because of this fault and Boeing have no intention of addressing it either
Why the cargo doors on pressurised cabin airliners open outwards instead of inward like the passenger doors? I really dont understand.
Buts its the MD80's (formally DC-9s) that scare me the most, they have so many glaring design flaws its almost a wonder they are allowed to remain in service.
Search for 'hanging by a thread' on youtube, basically a boeing 737 became a '737 convertable' mid flight, yet it still managed to land safley, that is one hell of plane (and in this case it had one hell of a crew). it reminded me of another part of Boeings history, where B-17s managed to returned home with an astonishing amount of battle damage.
Overal I still prefer Boeings over Airbus.