Unionemerald,
that sounds like a good tip, I'll give that a shot as I'm experiencing the same issue.
I have been doing very well in my current patrol and saving it regularly (using different saves, not overwriting previous saves). When I tried to load my previous save en route to my next patrol area I get a CTD. Loading a autosave in base caused the same issue but I think I tried on-leaving-base perhaps I need to try on-entering-base. Starting a new career using another name started up no problem. I'll try your suggestion and see if it works. If it does you may have come up with the solution to many members' previous problems.
I would add that this is probably the most save files I've used during a patrol. My usual habit is 3 save files (En route to loc, in loc, RTB) plus a couple of extra saves if I think it's necessary. No problems with that routine. This is my first CTD in a loooooooong time and seems to coincide with my many save files (most of them replay files). It seems to be a common theme in this current thread.
