I had a couple careers where I would get through the first couple of patrols okay but once I got past a certain date in-game I would CTD in the game, but always when crossing one particular area in the North Sea. It was the most bizarre thing. My saves would always load, though. I looked at everything I could think of related to that particular area that might have changed at that particular time in the game, and couldn't pinpoint anything that might be the cause of the CTDs.
Finally I just went through all my mods one by one until I found a combination where the CTDs didn't happen any more, even in that spot after the date in question. Since then I've been fine.
Don't know if you're using any mods other than GWX3, but at least in my case whatever the conflict was with my setup, it only became a problem after a certain date in-game had passed. So if you do have any other mods enabled it might not be a bad idea to remove them all, then re-enable them one by one, to see if one of them in particular is making it impossible for you to run the game after whatever the problem date seems to be.
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