ok your system specs look ok (not sure if you have the latest bios, but then im not sure if i do either lol)
i have the Q9550 with Gigabyte P35-DS3L and 4gb ram and a GT8800 @ 512mb video so we are pretty close to the same and i have no issues with the game.
just be sure you have the latest video drivers installed and i would check if there is a bios update for that board (its been a while so i need to check my bios too)
check for dust build up or slow turning fans, open the heat sink cover on the video card as dust will pack into areas you dont see and block airflow even though it looks ok.
if its not a heat related issue as Arclight suggested then chances are its a mod combo issue so give us the mods your using and the install order you used. also i would try my mod soup fix first before getting too involved in troubleshooting to see if thats all it is.
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