you haven't got any USB card connected? That can make auto play keep coming up or your cd rom drive not registering in bios. Could be many different reasons why its happening though.
Try MS
Autoplay Repair Wizard
http://www.microsoft.com/downloads/d...DisplayLang=en
''The Microsoft AutoPlay Repair Wizard scans your computer devices to find defective AutoPlay settings, and attempts to fix those it finds.''
Turn off Autoplay on all drives
http://www.howtogeek.com/howto/windo...nd-usb-drives/