You may very well have a corrupted save. As Pisces noted, if you have another save made earlier you can try loading that and see what happens. You will lose everything that happened after that save point, but at least you'll be able to continue your mission/patrol without having to start over completely.
Unfortunately the occasional corrupted save seems to be a known issue with the game.
Best advice for avoiding them: don't save submerged, or within contact range of land or any other vessel.
This means that before you save, you should submerge (if you're on the surface) and do a hydrophone check to verify that there are no sound contacts within range. Resurface and verify from the bridge that you cannot see land, other ships, or aircraft in any direction; then ask your WO for the nearest visual contact to verify that the game agrees there is nobody else around.
Also, modding should only be done (and this includes using JSGME to enable/disable "pre-assembled" mods) when you are in base between patrols. So if you've changed anything in your mod line-up, or edited any files manually, since exiting the game after that save, you can try to undo whatever changes you made and then reload to see if that solves the problem.
If none of that applies, you may just have gotten the odd corrupted save for reasons unknown and the only option will be to start again from the last save point that will load for you without crashing.
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