I've just installed FWE, Fellout, a few other mods I thought looked good, and made my own mod to remove all of the radscorpions from the wasteland (I can't stand them) and the experience is just great. Definitely more difficult and more engrossing, plus I don't have to worry about those dang radscorpions!
Thanks for the tips, Ducimus, this run through is sure to provide me with plenty of entertainment!