The only surefire trouble shooting method would be to wipe the drive and install a clean operating system.
But first it does sound like a hardware issue. Check the fan / heatsink on the CPU make sure that it is properly seated. Sometimes also the heatsink paste will dry out and break its contact between the cup and heatsink.
If its a socket 775 it is real easy to knock the heat sink loose so its not properly seated onto the cpu and will lead to this kind of behaviour.
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