If your running onboard sound, be sure to check your mobo manufacturer for the drivers they recommend (as well as bios related patches), this is especially true for realtek ac97 which has half a dozen reference boards out there, not all the realtek drivers will function properly. Also the realtek 6xx series uses auto sensing plug in's for your surround sound, be sure to run "sound effect" and confirm that it has detected the audio output device you use (ie. your speaker config), else you may have an issue. Beyond this, be sure that any modded sound fx meet the appropriate spec's, some of the 44khz stereo noises dont buffer properly using onboard, and cause memory to leak over time... (this is a game issue not a HW issue). I believe SB audigy's have this issue as well.
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