Save at sea is ok, just be on the surface, with nothing within 50KM of you, and you should be ok. Do not make any changes to the game, like adding or deleting mods while at sea, only when you are docked at home port between patrols. There is a save game bug that does crop up from time to time that no fix has been found for.
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"Some ships are designed to sink...others require our assistance." Nathan Zelk
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