As far as I know you can load up a new GUI in the middle of a career. You can not instal one in the middle of a patrol however. Basicaly wait 'till you get back to base befor instaling any mod is the general rule. Generaly speeking the mods that require you to start all over will have a not in the read me or instal instructions, there aren't many mods that require a restart though.
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