I'm just comparing your specs with those recommended by Ubi on the game box because as you know GWX was designed to work under the same specs.
'1.4GHz or faster, 512MB, 64MB minimum card'
Your well above everything so there isn't a specs problem here.
Possibly a memory stick starting to act up?
Crikey, the possibilities are endless.
I spent between ond and two hours yesterday performing a complete new installation with over 70 mods....I know you want to avoid that if possible, so how about disabling the mods, running the game and if that looks fine, enable a few at a time?
There is a faint possibility all the additional mods may have tipped your system over the edge.
PITA mate I know but that is all I can suggest