Interestingly enough, the US Navy spent a LOT of money calibrating satellites to measure those little buggers so they could track subs by their microscopic "wake". They had to send ships all over to get water samples at different depths to make a "map" for the satellites to notice differences.
At least that is what my flow cytometry tech told me, since according to him the first real use of flow was for this purpose. (Flow cytometry is technology for measuring microscopic particles for size and complexity, nowadays we use it to record numbers of cells and various characteristics of those cells).
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