Above TC32 your crew will neither fatigue nor gain any rest, so it's good to keep above this where possible.
If you use the esc key to return to port you lose 100 reknown, which is no big deal really unless you find yourself 100 short for a new boat or an upgrade in which case you'll kick yourself. I've only use return to base a couple of times when the game has slowed down so much that the return journey was going to be completely unbearable. I find it more satisfying to sail into port, it kind of finishes the mission up.
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