I too have experienced this problem with my Nvidia 7950gx2 cards. It only happens when I am in or near a port. Whether it is a friendly port or enemy port. I will usually have to go to nav map mode and go out to sea. Once there I alt-tab out then back again, and the problem is gone. While in port I just hold down the alt key (the 2 people I need to talk to can still be seen, as a yellow highlight) and walk towards them. This has been my only solution to play. Anoying for me, but still playable, just not around ports.
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