A loooooong time ago some info was given that you would be able to "unlock" new areas of operation. If that still holds and we are not talking about unlocking new quick missions I'd guess you unlock the med theatre by something and then have the ability to start from (a) port(s) there.
That said, even if we assume this is true for the final game (which is a pretty big leap given the age of that piece of info and the ammount of actual info we have on the game) the act of "unlocking" the above mentioned "new areas" of operation might be to break through Gibraltar. Would make sense. But I wouldn't bet on it.
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