I am inclined to agree that there isn't a whole lot you can do. An intervention might work (or might backfire), but you need the people he is closest to and cares most about involved in it. If you do it solo it will almost certainly blow up in your face (the person will probably go defensive, particularly if you approach it wrong).
But it doesn't hurt to try imho. I would try taking him aside when he is sober, etc and gently talk to him about it. Don't tell him what to do, or how to run his life. Show mainly that you are concerned, not angry or judging him. The important thing is to not put him on the defensive, but get him to open up and talk about it.
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