Gotta love it.
One of the wonderful handicapped key combinations took my keyboard away. To avoid a reboot, since the even CTRL-ALT-DEL wouldn't bring up the Task Manager, I had to force crash my boat into the ocean floor with the mouse and kill my career.
Sigh.
I'm lucky the water was so shallow, or I would've had to completely reboot. Once out of the game I was able to use the mouse to disable the silly handicapped key feature disabling my keyboard.
Go Windows!