Most new games that at least go back some years ( 3 - 6) run 90% of the time "no problems" on Vista, due to the "x86 Folder" ( I'm simplifing explantion here on purpose) where the game install like a back compability in the Vista enviroment.
Now, if it runs in Vista it will run to 99,5% in Win 7.
For example; see the Nvidia drivers in 64-bit that has the same v. numbers in both Vista and Win7 versions.
So bottomline: Be sure that SH5 will run just fine in Vista or Win7.
I think this will be the "easy" back compability, that it will run just super on both Vista and WIn7 32 bit or not and/or 64 bit or not.
Now, 32 bit and/or 64 bit will be another storyline when it comes to taking advantage of what hardware and usage of the enviroment where the hardware operates. The more games that hit the shelves, (read:"newer releases" ) will of course take more and more advantage of the 64-bit enviroment and handling.