I've been suffering quite a lot of these.
I've just taken to only playing when I know I have enough time to either complete a patrol in one sitting, or at most with one save, as I normally get away with it. It's only when the saves keep piling up that the CTDs seem to occur.
Very annoying though. Everything you achieve in this game takes time and effort, and even seeing a few days of patrol wiped out is frustrating.
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