Entropy and thermodynamics are paradigms, or better: theories or theoretical constructions. They make sense in that they match a lot of observation data, and are capable to bring new observations into an order that matches their claim. Nevertheless they are just theories. Like anything else in sciences is just subjective observation, and theory.
A
responsible scientist does not claim to know the ultimate truth, but he will always say: "our current model explains it like this, and this makes sense according to what we know so far, because..." Only religious zealots and narcisstic missionaries - or stupid scientists - claim to have ultimate explanations that will not see any further alteration in the future.
Hell, even Hawking has given up some years ago his life-long claim that the world could be explained in one final, ultimate formula or model. It seems he made the step from knowledge to wisdom.
Only wisdom can serve as an antidot to being stupid, while most people in responsible positions, who mess up the world and peoples' lives, are very knowing people indeed. It seems that knowledge alone is just a necessary but no adequate and sufficient condition to act intelligently. You can know a lot - and still be stupid.
Or as Spock put it in ST6:
"Logic is the beginning of wisdom - not it's end." 