SH3 runs fine for me on Vista64... actually I don't think I've found a game in my collection yet that doesn't run flawlessly.
...one thing though, after losing an optical drive, I had no desire to reinstall anything on my new Vista64 system with Starforce.
I just paid the $20 (at the time) and downloaded the Starforce-free direct2drive version which also came all pre-patched up! I wouldn't use that SH3 disk for anything other than a drink coaster.
I love my Vista-Pro install. The feature that allowed me to image the whole harddrive saves me about once a month (my kids play these internet-based games that wreak malware havoc on my system). So nice to push a button and have my system back to pristine order within minutes.
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