Yes, the savegame files and Carreer profile stuff are stored in your windows profile (My) Documents folder. You should make a copy of that SH3 folder in it, and put it back later.
BUT!!!! You have to make sure you re-install the game with the exact same mod-sequence as before. Or else the data in the savegames might be in conflict. So you better not have a very long list of enabled mods. Make sure you write them all down in the correct order.
Also, keep a copy of the mods inside of the MODS folder to use after reinstalling. (copy or move; as after de-install/deleting the SH3 install-folder they are lost) There is a hidden, and probably huge, backup folder that you don't need. So don't copy the entire MODS folder itself. Only the folders that you can see inside of it. When the game is installed (patched, polished, supermod-ed), install JSGME and recreate the MODS folder with it. Then copy back the individual mod-folders there. And enable them in the right order.
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