What mods are you running? If you're using the Merchant Fleet Mod you need the 4-GB patch. If you don't have 4 gigs of RAM to start with, you might need to buy more memory.
Other than that, my advice would be to uninstall all the mods and reload them, one at a time. Load one, test it, load another, test it. If it's a mod conflict this procedure should tell you exactly which mod is causing the conflict.
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“Never do anything you can't take back.”
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