JSCones is right. The main problem is that people will install the game into vista first and only read the thread after it is installed and they have a problem.
The obvious answer is to uninstall it then reinstall it the correct way.
Most people will want to try to fix it first, however.
To see what the problems are, I made a second install into my program files and I have to admit it is a pain in the ass (or arse in the British Commonwealth). CMDR doesn't work well either.
Suggestion: bite the bullet and reinstall.
