The Steam versions of Sonalysts' sims are very moody. First and foremost, have you tried disabling the Steam in-game overlay when the game is active? I have seen this resolve the problem for some people. It is not a guaranteed fix, but it is a start. If that doesn't work, try running the sim in compatibility mode (XP SP3) to see if it helps. I see this issue more on machines with Nvidia cards than Radeon, so this is a bit different.
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