First let me echo everyone elses comments here, fantastic effort for doing all this.
I too am having problems, with CTD's at various stages and various methods. I have followed the instructions, downloaded the mod a couple of times to ensure the newest version. The only .mep i can get to work without missing mods is the sobers.mep included with the mod download.
Using this results in the game CTD when trying to load back into the "Bunker" after the tutorial. I have also tried this on new careers, skipping the tutorial. I have also tried this from a fresh install, as the instructions say. With the Open Horizons mod only first time to do tutorial, then turn all mods on and load game. This is where the crash occurs...
For the sake of testing i have also tried starting a new career straight from scratch with all mods active, this also results in a crash trying to load the "Bunker" save game.
I'm still trying, as i really want to give this a proper play. I did manage to load an old save game of me at the start of the very first patrol. All looks incredible (which is why i am persisting). I engage the Harbour Pilot to take me outbound along the canal. So far so good...
Then CTD, once about 1/4 of the way down the kiel canal. Even does it if i try the other route around Denmark.
I hate to ask, but is there any chance you could look at doing make a streamline version .mep with a stable core that can then be added to by the user?
I'm going to have a play now on a fresh install, just installing various mods ontop of open horizons and see if can at least get into the game.
Here is the current .mep i am using so you are aware:-
Code:
Accurate German Flags
RemoveLogoIntroTheDarkWraith
DBM Background Video
sobers green spinning thing SH5
sobers game loading tips SH5
Real Environment - Revision_3
sobers best ever fog V20 SH5
sobers base sky mechanics V1
sobers better terrain v3 SH5
sobers waves mod V7 01012013
North Atlantic Green 1.1
Small_trees_SH5_V1
sobers see thru wake fix
sobers_realistic_underwater_FX2
Window_Lights_Redone_V1
Pascal-sh5-Crew-Uniforms
SteelViking's Interior Mod V1.2
SteelViking's Interior Mod V1.2.2 Patch
silentmichals interior mod 1.2.1
SH5_7A_Conning_Fix
Fuel Gauge WoGaDi_SteelViking's Interior
Speech fixes and additions (english version)
Equipment_Upgrades_Fix_v1_4_byTheBeast
#Equipment_Upgrades_Fix_v1_4_Patch_1_HotFix
Eqp_Upgrades_fix_v1.4 dates by sober Patch V2
NOZAURIO'S SKIN (Standar No Emblem) v-1.1.0
SH5 Longer Repairs v.1
AI_sub_crew_1_0_2_TheDarkWraith
FX_Update_0_0_19_ByTheDarkWraith
NewUIs_TDC_7_2_0_ByTheDarkWraith
NewUIs_TDC_7_2_0_alt_officer_wounded_by_Torpedo
NewUIs_TDC_7_2_0_Real_Navigation
NewUIs_TDC_7_2_0_RadCapTools_0_2_alpha
Manos Scopes-patch for 16x9
IRAI_0_0_37_ByTheDarkWraith
TDW_Ship_Inertia_1_1_0
TDW_IRAI_Inertia_Damage_Test
TDW_No_Hydrophone_On_Surface_1_1_0
Cerberus62 Corrected Depth Charge Projector 1.0
KZS Hull wetness for U-Boats + co tower and deck_revised_by_TheDarkWraith
3D_Deck_Splash_FX_v1_0_0_byTheBeast
3D_Deck_Splash_FX_v1_0_0_KZS_Compat_byTheBeast
Sub_Bubbles_v0_0_3_ byTheBeast
OPEN HORIZONS II_full v2
OHII v2 Mission Fix WA
Expanded Navies by Cybermat47 v.1.0.0
Reworked Morale and Abilities v.1.1
MightyFine Crew Mod 1.2.1 Alt faces
MCCD_1.04_MFCM_1.2.1_compatible
sobers green crew training V4 SH5
TDW FX Fix for Sobers chimney smoke
Church's Compass Dials Mod v2.2 - Option Two
OH II Minefield map for TDWs Ui
Grossdeutscher Rundfunk
sobers NO water drops V1
smaller flags for Warships 1_0b
sobers Lights Cfg V5 SH5
Trevally Tutorial - All v0.2(for OHIIv1.3)
Trevally Automated Scripts v0.6
Trevally Harbour & Kiel Canal Pilot v2.9
MadMaxs_SH5_Subdiesel (mono) v2
gap - Sonar Sound Collection v 1.0 for SH5 - Distorted
sobers hud sounds V1 SH5
sobers no footstep sound mod
sobers DOF V3 SH5
EQuaTool 01.01 by AvM - Large Style
AOB slide ruller for TDW UIs and MO by stoianm
gap - HD 1 deg Scope Bearing v 1.0
Shadow Improvement ModLR
sobers bad weather deck gun V1 SH5
EDIT: I will try what is suggested below, first.