Are you able to run any training missions with GWX installed? Does it just fail when you attempt campaign mode? Or does the whole thing fail?
I don't know if this will help, but I was running into trouble in Win10, but only when loading / running campaign. I set compatibility on the SH3.exe to WinXP SP2, and that seemed to rectify the problem... at least thus far.
Anything else loaded besides GWX? What GWX mods do you have enabled?
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