I've had no problem playing this game on Vista to be honest. Didn't need to adjust anything, ran right out of the box (well, there was no box - I bought it via Steam). Runs perfectly well on my laptop with Vista Home Premium. Haven't tried it on my desktop with XP but I wouldn't expect problems there either.
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There are only forty people in the world and five of them are hamburgers.
-Don Van Vliet (aka Captain Beefheart)
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