I recently installed SHIII from my old CD and it went on and updated without issue, and I am running Vista x64 Home Premium. The only issue I encountered was when I started the game, and the Starforce protection nonsense would not run on Vista. I used the Starforce removal tool and replaced the .exe files as instructed by their site, and I never looked back. I did not have to change admin priveliges or anything else, just remove the DRM nonsense and it starts first time.
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