As someone who's played somewhere in the neighbourhood of 100 hours of Misery, I can't say I've ever had any problems with it - and getting it to run was not an issue either. It's a simple installer which will configure it for you. Just make sure you install it on top of a fresh Call of Pripyat with no other mods.
The current (final) version of Misery is very stable, and even includes an "easier" mode, as far as I remember.
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There are only forty people in the world and five of them are hamburgers.
-Don Van Vliet (aka Captain Beefheart)
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