Almost all crashes I had were related to sound mods. OMEGU introduces sounds, OM does not.
A simply test is to backup all sound files from the vanilla game, and to overwrite everything with the default files if there is a problem. At one point in the past I could establish that my crashes were gone afterwards, and I could then reduce my sound mods to a minimum. I have no crashes since then.
I also reduced sound to "no acceleration" in DxDiag, since I saw this as a recommendation in the past.
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