Hello mattinkent,
Does the game run properly without the wideGUI mod? Asking just to narrow things down.
I had the same problems before and I'm not 100 % sure what did the trick but after trying the tips on the dedicated thread I've no been CTD free for a while:
http://www.subsim.com/radioroom/show...215433&page=25
If that specific wideGUI mod gives you problems maybe you should try another one to be sure.