1 in 3 ??
Now that you have (likely) located the problem, I would completely uninstall the game, delete all folders, open the registry and delete this key if still there:
HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Ubisoft\Si lent Hunter 5
Then re-install all again fresh.
Problem is I don't know about the U-Play crap, I've done so I don't have trouble in this regard.
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