Hi Bishie
As mentioned by itadriver you also need the 4gb patch.
Game ctd's when loading a saved game is a classic Windows compatibility problem.
If you are running Windows 10 then you need Windows 7 compatibility mode.
SH3.exe
GWX
SH3Commander
JSGME
Run all these as administrators.
Make sure your GPU drivers are up to date and your settings are correct.
Post #239 Changing The Nvidia GPU Settings
Post #240 Changing AMD Radeon GPU Settings
SFSF-MODULE - The New Solution for "Steam" & "Starforce"
Peter