[THEBERBSTER]

A Warm Welcome To The Subsim Community > Einheerjar
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SH3 – 4 - 5 Tutorials > Downloads > Other Useful Information > See Links in My Signature Below

have no mod running in the MOD-Manager except this one.

Which one? You do not say.
TWoS installs directly without using JSGME as you no longer see the main mod or any updates.

The one mod you maybe referring to being enabled in JSGME is Real Navigation.

Your problem is not one of compatibility as SH5 will run on Windows 10 without it.
You need to make sure that your gpu is setup correctly as this is important.
Changing The Nvidia GPU Settings > Essential Settings > Pictorial

This option can be added if still a problem and often sorts a problem if your system has been updated by Microsoft.
Override High DPI Scaling Behavior > Pictorial

Another problem can be Direct X 9c an essential application for all SH versions is not installed or not installed correctly.

Do you have more than 1 SH5 installation?
This can be done without problems but has to be done correctly.