Vista x64 here.
No need to run in compatibility mode or as Administrator. Only thing to watch out for was to run the 1.4b patch as an Administrator (it didn't prompt me to so it would have never succeeded). At first I was getting a bunch of CTDs etc, but reran the entire setup making sure to launch the 1.4b patch elevated and it worked just fine after that (GWX 1.03).
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