The requests to design for LW/Ami originated back in the days of 1.01, when detection ranges were significantly different between the stock and modded versions. That DID make a huge difference, so it was important to keep that in mind when designing missions. I think a lot of people hear about missions designed for LW/Ami and think that it's still a big issue today, and a good majority of the requests to design for it are based on this out-of-date perspective.
So, unless it's clear that there is a specific, relevant difference that the requester would like to see put to good use in a new mission (say for example, AI helo prosecution), I wouldn't sweat it too much.
In a sense, it's actually stock DW that you may have to design missions specifically for, since the main difference between stock and LW/Ami is that in LW/Ami, platforms and weapons work the way they're supposed to. In stock, you may have to compensate for things not doing their jobs.
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