Depends on which sim you use it with I guess. Some sims will support multiple joysticks at the same time (FS for example), others won't like it at all, although a splitter might be able to get it working in other sims. Whenever I've tried doing stuff like that, sometimes it's worked, sometimes not, so I think it's a case of 'suck it and see' which isn't ideal given the cost of stuff like that.
But even if that was the case and it worled (which I think is likely), presumably what your're talking about is having throttle on one stick, control surfaces on another (apart from rudder), and rudder on yet another stick, for a total of three sticks. Which sounds a bit cumbersome to me, but if you could put up with it, then I suppose that'd be okay.
I imagine you could put up with having 'automatic rudder' selected, which many sims will let you use, but that makes sideslipping impossible.
Chock