Keesh, do you have a 64bit OS and ram above 4gb? Because if not, there is no point for the 4gb patch.
If yes, do what hauangua said: after a clean installation, install GWX and run the game to see if there is a CTD. If not, proceed to enable one mod at a time and run the game to see what could be the one causing the CTD.
Normally I enable first the GWX mods and they they not be a problem.
After them I recommend the FM_Interiors, since its a heavy mod and can cause some disruption. Ex: I can not run Fm_interiors mod in my PC, both versions; why, I can not tell (possibly some lack of memory since I have a 32bit system, but could run it with my previous PC that had XP 32bits and less ram memory...).
If you can run the game fine, than processed to the others and so one.
The last should be the h.sie patch.
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