Read manual
Read manual because most problems with CTD is known.
Never save a game while underwater.
Avoid saving game with enemy contact.
4 GB patch is not "must have" if you use clean GWX mod only.
But almost all GUI's waste RAM with nonsense big 32-bit textures as example. This is especially true for full HD.
I can play clean GWX/1600x900 without any CTD on Windows XP/SP2 with 1,5GB physical RAM and no windows swap file.
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