Joe Biden has told Benjamin Netanyahu that US support for Israel will depend on steps being taken to "address civilian harm" and "humanitarian suffering"
The US president and Israeli prime minister were speaking for the first time since an Israeli strike killed seven aid workers in Gaza on Monday.
Biden told Netanyahu the strike and "overall humanitarian situation" in Gaza are "unacceptable", the White House says.
Israel is yet to issue its readout of the call - but said earlier this week the incident was a "grave mistake" and promised an independent investigation.
As a result of the strike, some aid groups have paused operations, increasing concerns about starvation in the north of the Strip.
The BBC's Gaza correspondent Rushdi Abualouf says residents there are living in tragic, near-famine conditions.
Meanwhile, the UK government is under pressure to suspend arms sales to Israel - more than 600 legal experts have written to PM Rishi Sunak saying exports must end.
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