Windows 10 hasn't been a problem (so far) after I fixed my shortcut properties for the desktop icon. Unfortunately that took me a while to sort out.
- Compatibility mode (Windows 7)
- Run this program as an administrator
- Start in: "C:\Program Files (x86)\Ubisoft\SilentHunterIII"
The last one was causing it to crash after the startup splash screen. I figured that out by accident when I realized that it ran when I started from the sh3.exe file, but not from the start menu shortcut.
I'm running an AMD Radeon HD 7700 graphics card. After I turned on GPU scaling it worked fine.