Well, we've been collecting collateral for a while, I mean you can do your best to avoid civilian collateral but sometimes it will happen no matter what you do. Hellfire missiles and laser guided bombs have a blast radius which will not only kill the jihadi but anyone within a good few feet of him or her.
The Jihadis know that we try to avoid collateral so they will use civilians as shields, it's a classic trick, one of the oldest...heck, Saddam did it often enough.
That's why I put a lot of hope on the ARSS and the possibility of guided bullets and micro-missiles. If we can increase the lethality and accuracy of our shots while decreasing the lethal radius, then we can cut down on collateral and the negative side-effects that it has.
Of course, the down-side of stand-off warfare is that you need good intel, and I think that's where we've struggled a fair bit.
