Just had a CTD when starting a brand new career. I did notice something funny about how it happened. Since I had already finished the tutorial mission it asked me if I wanted to skip the Tutorial. Naturally I said yes. So I went and got my mission orders and then selected start new patrol. Now usually as soon as you click the start new patrol you get the loading screen for a little while and then you are on your uboat. This didn't happen this time

So I proceeded on as normal and as soon as I got into the harbor CTD!
I deleted the career (it was a brand new one) and started a new career. This time as soon as I was in the bunker I saved my game and exited the game. Restarted the game and reloaded my newly saved career. Went and got my mission orders and selected start the new patrol and got the loading screen and no CTD.
So be warned - when starting a new career and you elect to skip the tutorial save career, exit game, restart game, reload newly created career to avoid a CTD